vitamin d receptor type

2018;8(1):31. Stang A. Rasheed MA, Kantoush N, Abd el-Ghaffar N, Farouk H, Kamel S, Ibrahim AA, et al. Zhong X, du Y, Lei Y, Liu N, Guo Y, Pan T. Effects of vitamin D receptor gene polymorphism and clinical characteristics on risk of diabetic retinopathy in Han Chinese type 2 diabetes patients. Bmj. Angel B, Lera L, Márquez C, Albala C. The association of VDR polymorphisms and type 2 diabetes in older people living in community in Santiago de Chile. PubMed  The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D. VDR regulates the expression of numerous genes involved in calcium/phosphate homeostasis, cellular proliferation and differentiation, and immune response, lar …. First of all, the VDR-Bsm Ι polymorphism was compared between type 1 diabetic patients overall and healthy subjects. Association of Vitamin D Receptor Gene Polymorphism in adults with type 2 diabetes in the Kashmir Valley. Association of vitamin D and vitamin D receptor gene polymorphisms with chronic inflammation, insulin resistance and metabolic syndrome components in type 2 diabetic Egyptian patients. Clin Endocrinol Metab 86 , 1908 – 1912 . Distribution of VDR gene polymorphism in patients with type 1 diabetes overall and controls. Type 2 diabetes mellitus: association study of five candidate genes in an Indian population of Guadeloupe, genetic contribution of FABP2 polymorphism. (19) studied the relationship of the VDR gene polymorphism to autoantibodies (GADA, IA-2 antibody) and found no significant relationship among them. The Bonferroni correction for multiple comparisons was performed, where appropriate. Similarly, the prevalence of other HLA types (HLA-DR9, A24, and Bw54) in acute and slow-onset patients was 49.2% and 47.8%, 69.6% and 51.2%, and 34.8%, and 19.5%, respectively; and there was no significant difference between acute-onset and slow-onset type 1 diabetics regarding these HLA types in this study. Vitamin D receptor gene FokI but not TaqI, ApaI, BsmI polymorphism is associated with Hashimoto’s thyroiditis: a meta-analysis. However, the findings were inconclusive. Nearly every tissue and cell type in your body has receptors for vitamin D, thereby increasing the amounts needed for optimal health. Int J Vitam Nutr Res. Eur J Endocrinol. Ozougwu J, et al. Mathieu C, Gysemans C, Giulietti A, Bouillon R. Vitamin D and diabetes. By assessing the existence of islet-antigen-reactive T cells in the peripheral blood from those patients, it may be possible to evaluate the pathophysiology in relation to the VDR gene polymorphism in a future study. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detection. Slow-onset type 1 diabetes was diagnosed based on islet-associated autoantibody positivity, and the period from diabetes onset to insulin treatment was more than 12 months, in this study. Referring to the VDR gene sequence (accession no. Nature. Kautzky-Willer A, Harreiter J, Pacini G. Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus. Abstract. AA, ME and SR performed statistical analysis, interpreted data, drafted the manuscript. Can J Diabetes. Considering these results, we speculate that the regeneration of pancreatic islet cells and immunoregulatory effects may independently influence the pathophysiology of type 1 diabetes, although accumulation of more data is needed to reach a conclusion. The frequency of B allele in slow-onset type 1 diabetics was not significantly different from that in controls (Table 2). Evidence from various studies suggest that vitamin D receptor (VDR) gene polymorphisms are associated with type 2 diabetes (T2D); However, these results have been disputable. 8(4). Mackawy AM, Badawi ME. Asian J Pharm Clin Res. Google Scholar. In the analysis of allele frequencies, there was a significantly higher frequency of B allele in type 1 diabetics overall, compared with the controls as well (P < 0.0001) (Table 1). Association of vitamin D receptor gene polymorphism with multiple sclerosis in Japanese. Vitamin D Receptor gene polymorphisms and susceptibility to type 2 diabetes: evidence from a meta-regression and meta-analysis based on 47 studies. Moreover, 1,25(OH)2 D3 could prevent the recurrence of autoimmune disease after syngeneic islet transplantation (31, 32), and administration of GAD65 and 1,25(OH)2 D3 to NOD mice changed the autoantigen-specific cytokine balance in this model (33). Sergeev IN, Rhoten WB. In studies of type 1 diabetes in Taiwanese, it has been shown that type 1 diabetes was associated with B allele (19). 2017;10(10):248–52. Asia Pac J Clin Nutr. Vitamin D receptor gene polymorphisms and HLA DRB1* 04 cosegregation in Saudi type 2 diabetes patients. Journal of Diabetes & Metabolic Disorders Psychol Methods. However, no association was found with the TaqI and ApaI polymorphisms. Diabetes. 2006;11(2):193–206. 2002;51(3):356–9. Clin Interv Aging. Google Scholar. Moreover, there was a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls (P = 0.0002), whereas this difference was not observed between slow-onset type 1 diabetics and controls. Type 1 diabetes mellitus is recognized as a T-cell-mediated autoimmune disease. Journal of Basic and Clinical Pharmacy, 2017. Al-Daghri NM, et al. Wang X, et al. When at least one of GADA, IA-2 antibody, and IAA was positive, those patients were defined as “islet-associated autoantibody positive,” although none of the patients were positive for IAA only. Lu, S., et al., The associations between the polymorphisms of vitamin D receptor and coronary artery disease: a systematic review and meta-analysis. Google Scholar. Moreover, onset age did not affect the distribution of genotype frequencies in type 1 diabetic patients, because there was no significant difference between patients above and below the mean onset age in each subgroup (groups A, B, and C). https://doi.org/10.1007/s40200-020-00704-z. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows similarity of sequence to the steroid and thyroid hormone receptors. After obtaining informed consent from the recruited subjects, we extracted DNA from peripheral blood. Skorpen CG, et al. The study of CTLA-4 and vitamin D receptor polymorphisms in the Romanian type 1 diabetes population. This hormone inhibits T-cell activation both in vitro and in vivo and inhibits secretion of cytokines such as IL-1, IL-2, IL-6, IL-12, TNF, and interferon-γ (9–11), which are believed to be involved in the pathogenesis of autoimmune diseases (12). Journal of clinical & translational endocrinology. Although the frequencies of HLA A24 and Bw54 in acute-onset type 1 diabetics were higher than those in slow-onset type 1 diabetics, the differences did not reach statistical significance in our study. Ofstad AP, Atar D, Gullestad L, Langslet G, Johansen OE. Vural H, Maltas E. RT-qPCR assay on the vitamin D receptor gene in type 2 diabetes and hypertension patients in Turkey. The nuclear receptor superfamily: the second decade. 2015;566(2):212–6. Rivera-Leon E-A, Palmeros-Sanchez B, Llama-Covarrubias IM, Fernandez S, Armendariz-Borunda J, Gonzalez-Hita M, et al. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Reis, G.V.O.P.d., et al., Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review. Zaccardi F, Webb DR, Yates T, Davies MJ. We studied the association between T1DM and the initiation codon polymorphism in exon 2 of the vitamin D receptor gene in a Japanese population. The major physiological role of the vitamin D receptor (VDR) is the maintenance of mineral ion homeostasis. PubMed  This interaction allows VDR to partner with another protein called retinoid X receptor (RXR). Expression of JAZF1, ABCC8, KCNJ11and Notch2 genes and vitamin D receptor polymorphisms in type 2 diabetes, and their association with microvascular complications. 1,25-Dihydroxyvitamin D3 prevents insulitis in NOD mice. Type-1 diabetes: a chronic autoimmune disease of human, mouse and rat. Regardless of the existence of islet-associated autoantibody, we found a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls. J Immunol. In a subpopulation study, we defined group A as acute-onset type 1 diabetics without islet-associated autoantibody, group B as acute-onset type 1 diabetics with islet-associated autoantibody, and group C as slow-onset type 1 diabetics with islet-associated autoantibody. Vitamin D has been shown to exert manifold immunomodulatory effects. Dear Editor, we read the publication on “Association of Vitamin D receptor (VDR) gene BsmI polymorphism with type 2 diabetes mellitus (T2DM) in Pakistani population” with a great interest. Independently reviewed in 5 review(s). Preferred Reporting Items for Systematic reviews and Meta-Analyses, Interferon; HWE, Hardy–Weinberg equilibrium. PubMed  2018;22(2):229–35. Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, et al. In acute-onset patients, regardless of the existence of islet-associated autoantibody, there was a significant difference in B allele frequency between type 1 diabetics and controls (Tables 33 and 44). Mutations in this gene are associated with type II vitamin D … Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure strength of association. RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES. Gene. 2019;35(2):146–9. 33(2). 2010;9(4):2060–8. CAS  Hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR, OMIM 277440), also known as vitamin D-dependent rickets type II, is a rare autosomal recessive form of vitamin D resistance due to loss of functional vitamin D receptor (VDR)[].The VDR is expressed in most tissues of the body, including intestine, kidney, bone, and keratinocyte of hair follicles [2, 3]. Todd JN, Srinivasan S, Pollin TI. Ye W-Z, Reis AF, Dubois-Laforgue D, Bellanné-Chantelot C, Timsit J, Velho G. Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset. Nutrition & diabetes. Genet Mol Res. PubMed Central  Google Scholar. Article  J Investig Clin Dent. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, et al. Huedo-Medina TB, Sánchez-Meca J, Marín-Martínez F, Botella J. Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Recently, some VDR gene polymorphisms were shown to be associated with autoimmune diseases (19–27). Dong X, et al. Lee S, Clark SA, Gill RK, Christakos S. 1, 25-Dihydroxyvitamin D3 and pancreatic beta-cell function: vitamin D receptors, gene expression, and insulin secretion. Google Scholar. 1991;49(3):668–73. In healthy subjects, the distribution of genotypes was not significantly different from the expectation under Hardy-Weinberg equilibrium.

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